Rantalliz

Ovarian Cancer

Overview

Ovarian cancer is a growth of cells that forms in the ovaries. The cells multiply quickly and can invade and destroy healthy body tissue.
The female reproductive system contains two ovaries, one on each side of the uterus. The ovaries — each about the size of an almond — produce eggs (ova) as well as the hormones estrogen and progesterone.
Ovarian cancer treatment usually involves surgery and chemotherapy.

Who gets ovarian cancer?

Ovarian cancer affects women and people assigned female at birth (AFAB). It’s slightly more common in Native American and white populations than in people who are Black, Hispanic or Asian.

 

In addition, people of Ashkenazi Jewish descent are much more likely to have a BRCA gene mutation, placing them at a higher risk for breast and ovarian cancer.

When ovarian cancer first develops, it might not cause any noticeable symptoms. When ovarian cancer symptoms happen, they’re usually attributed to other, more common conditions.

 

Signs and symptoms of ovarian cancer may include:

 

  • Abdominal bloating or swelling
  • Quickly feeling full when eating
  • Weight loss
  • Discomfort in the pelvic area
  • Fatigue
  • Back pain
  • Changes in bowel habits, such as constipation
  • A frequent need to urinate

It’s not clear what causes ovarian cancer, though doctors have identified things that can increase the risk of the disease.

 

Doctors know that ovarian cancer begins when cells in or near the ovaries develop changes (mutations) in their DNA. A cell’s DNA contains the instructions that tell the cell what to do. The changes tell the cells to grow and multiply quickly, creating a mass (tumor) of cancer cells. The cancer cells continue living when healthy cells would die. They can invade nearby tissues and break off from an initial tumor to spread (metastasize) to other parts of the body.

The type of cell where the cancer begins determines the type of ovarian cancer you have and helps your doctor determine which treatments are best for you. Ovarian cancer types include:

 

  • Epithelial ovarian cancer.This type is the most common. It includes several subtypes, including serous carcinoma and mucinous carcinoma.
  • Stromal tumors.These rare tumors are usually diagnosed at an earlier stage than other ovarian cancers.
  • Germ cell tumors.These rare ovarian cancers tend to occur at a younger age.

Factors that can increase your risk of ovarian cancer include:

 

  • Older age.The risk of ovarian cancer increases as you age. It’s most often diagnosed in older adults.
  • Inherited gene changes.A small percentage of ovarian cancers are caused by genes changes you inherit from your parents. The genes that increase the risk of ovarian cancer include BRCA1 and BRCA2. These genes also increase the risk of breast cancer.

Several other gene changes are known to increase the risk of ovarian cancer, including gene changes associated with Lynch syndrome and the genes BRIP1RAD51C and RAD51D.

 

  • Family history of ovarian cancer.If you have blood relatives who have been diagnosed with ovarian cancer, you may have an increased risk of the disease.
  • Being overweight or obese.Being overweight or obese increases the risk of ovarian cancer.
  • Postmenopausal hormone replacement therapy.Taking hormone replacement therapy to control menopause signs and symptoms may increase the risk of ovarian cancer.
  • Endometriosis is an often painful disorder in which tissue similar to the tissue that lines the inside of your uterus grows outside your uterus.
  • Age when menstruation started and ended.Beginning menstruation at an early age or starting menopause at a later age, or both, may increase the risk of ovarian cancer.
  • Never having been pregnant.If you’ve never been pregnant, you may have an increased risk of ovarian cancer.

Despite years of research, experts haven’t yet developed a successful ovarian cancer screening test. For this reason, the condition is often difficult to diagnose in the early stages.

 

If your healthcare provider suspects ovarian cancer, they’ll ask about your symptoms and perform a pelvic exam. During the exam, they’ll check for any abnormal growths or enlarged organs.

 

They may recommend additional tests, including:

 

Imaging tests

Providers may use several imaging tests, including:

 

  • Pelvic ultrasound.
  • MRI (magnetic resonance imaging).
  • CT scan (computed tomography).
  • PET scan (positron emission tomography).

Blood tests

Blood tests look for a substance called CA-125. High levels of CA-125 in your blood can be a sign of cancer. However, CA-125 levels can be normal, even when cancer is present, and higher in many conditions that aren’t cancer. Because of this, providers use blood tests in combination with other tests to diagnose ovarian cancer.

 

Surgical evaluation

 

Providers can diagnose ovarian cancer during surgery. Typically, if they find abnormal growths, they’ll remove them during the same procedure.

 

Laparoscopy

 

During laparoscopic surgery, a surgeon places a thin camera (laparoscope) through a small cut (incision) made in your abdomen. Using the scope as a guide, along with additional ports to hold instruments, the surgeon can assess the cancer, perform staging biopsies and, in some circumstances, remove ovarian tumors.

There’s no sure way to prevent ovarian cancer. But there may be ways to reduce your risk:

 

  • Consider taking birth control pills.Ask your doctor whether birth control pills (oral contraceptives) may be right for you. Taking birth control pills reduces the risk of ovarian cancer. But these medications do have risks, so discuss whether the benefits outweigh those risks based on your situation.
  • Discuss your risk factors with your doctor.If you have a family history of breast and ovarian cancers, bring this up with your doctor. Your doctor can determine what this may mean for your own risk of cancer. You may be referred to a genetic counselor who can help you decide whether genetic testing may be right for you. If you’re found to have a gene change that increases your risk of ovarian cancer, you may consider surgery to remove your ovaries to prevent cancer.